Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation
Dysregulation of Fibroblast Growth Factor Receptor (FGFR) signaling through amplifications, mutations, and gene fusions has been implicated in a broad array of cancers (e.g. liver, gastric, ovarian, endometrial, and bladder). ARQ 087 is a novel, ATP competitive, small molecule, multi-kinase inhibitor with potent in vitro and in vivo activity against FGFR addicted cell lines and tumors. Biochemi...
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Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in many cancers, including intrahepatic cholangiocarcinoma (ICC). The FGFR inhibitor BGJ398 displayed encouraging efficacy in patients with FGFR2 fusion-positive ICC in a phase II trial, but the durability of response was limited in some patients. Here, we report the molecular basis for...
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Encephalomalacia is softening or loss of brain tissue following cerebral infarction; cerebral ischemia infection, craniocerebral trauma or other injuries. Cholangiocarcinomas are malignant neoplasms of biliary epithelium, which usually arise from the intrahepatic ducts. A budgerigar was presented with a history of ataxia, decreased activity, neck weakness and weight loss. Supportive care was at...
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BACKGROUNDS Prognosis for patients with advanced intrahepatic cholangiocarcinoma (ICC) with intrahepatic metastasis (IM), vascular invasion (VI), or regional lymph node metastasis (LM) remains poor. The aim of this study was to clarify the indications for surgical resection for advanced ICC. METHODS We retrospectively divided 213 ICC patients treated at Kyoto University Hospital between 1993 ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2018
ISSN: 0007-0920,1532-1827
DOI: 10.1038/s41416-018-0334-0